Paf reading certificate2/14/2023 The study analysis was conducted after the volunteers reported the receipt of the second vaccine dose to assess the impact of complete activation of the human immune system. The researchers obtained blood samples after overnight fasting from a total of six healthy women prior to vaccination, and three weeks and five months after COVID-19 mRNA vaccination. ![]() The team collected bovine serum albumin fraction V (FV-BSA), ADP, PAF, collagen, and thrombin receptor activating peptide (TRAP) along with a recombinant HEK293-derived SARS-CoV-2 S receptor-binding domain (RBD) protein. In the present study, researchers evaluated the effect of the COVID-19 messenger ribonucleic acid (mRNA) vaccine on the human platelet-rich plasma (hPRP) aggregation response and whether a recombinant SSARS-CoV-2 S protein could modulate hPRP aggregation induced by PAF. Furthermore, various studies have reported stimulation of tumor necrosis factor-α (TNF-α), platelet factor 4 (PF4), interleukin 1β (IL-1β), and IL-8 from platelets by the SARS-CoV-2 S protein. Platelets play a crucial role in thrombosis and homeostasis and their aggregation has been widely reported among coronavirus disease 2019 (COVID-19) patients as a response to collagen, thrombin, and adenosine diphosphate (ADP). Study: Is there an interplay between the SARS-CoV-2 spike protein and Platelet-Activating factor? Image Credit: PHOTOCREO Michal Bednarek/Shutterstock ![]() In a recent study published in the IUBMB journal, researchers assessed the association between platelet-activating factor (PAF) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein. By Bhavana Kunkalikar Reviewed by Aimee Molineux
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